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I have never injured a joint but, my sister has and she was in big pain so she must've felt miserable. It was hard for her to write with her dominant hand after she got hurt.
I think that without knuckles, It would be very hard to live without. I feel like knuckles are very important
Without this joint, It would be very hard to throw a ball, write on a piece of paper, pick up things, ect;.